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Trimethoprim and sulfamethoxazole inhibit successive steps in the folate synthesis. Sulfamethoxazole is an analogue of p-aminobenzoic acid (PABA) and inhibits enzyme, dihydropteroate synthetase. Trimethoprim inhibits synthesis of tetrahydrofolic acid by interferring in the action of bacterial dihydrofolate reductase enzyme. Folic acid is an essential precursor in the synthesis of DNA nucleosides thymidine and uridine. DNA nucleosides thymidine and uridine is required by the bacteria for DNA replication and transcription. Trimethoprim and sulfamethoxazole are not synergistic in action. Due to the popularity of the drug, it is easily available world over. Generic versions have also been introduced and you can enjoy heavy volume discounts when you buy Bactrim online from our online pharmacy. Learn More...

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Brand Name: Bactrim	Tell a Friend

Generic Bactrim Pills

FAQ about Generic Bactrim

How does Bactrim work?
Sulfamethoxazole is a sulfonamide antibiotic and Trimethoprim is a diaminopyridine antibiotic. Sulfamethoxazole inhibits folate synthetase enzyme and Trimethoprim inhibits bacterial dihydrofolate enzyme. Trimethoprim is more active against bacterial dihydrofolate reductase enzyme. Hence human folate metabolism is not interferred at antibacterial concentrations of Trimethoprim.

Side effects of Sulfamethoxazole and Trimethoprim
The common side effects reported with Bactrim are nausea, vomiting, diarrhea, loss of appetite, headache, muscle weakness, mental/mood changes, goiter, blood in the urine, change in the amount of urine, confusion, persistent headache, neck stiffness and seizures.

Guidelines before using Sulfamethoxazole and Trimethoprim
Bactrim should not be taken during pregnancy. Trimethoprim being an antifolate there is a theoretical teratogenic risk. Bactrim can cause neonatal haemolysis and methemoglobinemia when given in the last term of pregnancy. When Bactrim is given to patients with renal disease, they may develop uremia. The dose of Bactrim should be reduced in severe renal impairment. A high incidence of fever, rash and bone marrow hypoplasia due to Sulfamethoxazole and Trimethoprim combination has been reported among AIDS patients with pneumocystis carnii infection. The elderly are at greater risk of bone marrow toxicity from Bactrim. Diuretics when given along with Bactrim have produced a higher incidence of thrombocytopenia.

What are the common dosages of Bactrim?
The recommended starting dosage of Bactrim in adults is 2 Bactrim tablets twice daily for 2 days and then dose is reduced to 1 Bactrim tablet. One Bactrim tablet consists of 80mg of Trimethoprim and 400mg of Sulfamethoxazole. The recommended dose in children is 20mg Trimethoprim and 100mg Sufamethaoxazole.

Difference between Brand and Generic Bactrim
Price is the major difference between brand and generic Bactrim. You can easily buy cheap Bactrim when it is generic version compared to brand. Generic Bactrim is equivalent to the brand in all respects and undergoes intensive testing before being introduced in the market. The active ingredients are Sulfamethoxazole and Trimethoprim in both brand and generic Bactrim and hence there is no difference in the mechanism of action.

Where and How to buy Sulfamethoxazole and Trimethoprim
It is now easy and simple to buy Bactrim. You can order Bactrim from our online pharmacy and have it delivered at your doorstep without any hassles. There are several volume discounts you can avail when you purchase Bactrim medicine from our online pharmacy. Our generic drugs are safe and of the highest quality but available at the cheapest prices.

Why is the price of Bactrim so cheap at Qualitygenrics.com?
At Qualitygenrics.com, we sell only generic drugs. This implies that we have no expenses towards the research or development of the drugs. We manufacture generic drugs after the patent for it has expired. Since we have no start-up costs, you can buy cheap Bactrim online from us. Our drugs are manufactured under strict quality control procedures and hence there is no compromise on the quality or safety of the drug because of a cheaper price.

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